Syntheses of Pyrido [2, 3-b] pyrazine Derivatives
نویسندگان
چکیده
منابع مشابه
Methyl pyrido[2,3-b]pyrazine-3-carboxylate
The asymmetric unit of the title compound, C(9)H(7)N(3)O(2), is composed of two independent mol-ecules. The crystal structure is stabilized by C-H⋯O and C-H⋯N hydrogen bonds, forming a three-dimensional network. The crystal structure also features pyrazine-pyrazine π-π inter-actions [centroid-centroid distance = 3.6994 (5) Å] and also pyridine-pyrazine π-π inter-actions [centroid-centroid dista...
متن کامل2-(4-Fluorophenyl)-3-(4-pyridyl)pyrido[2,3-b]pyrazine
In the crystal structure of the title compound, C(18)H(11)FN(4), the pyridopyrazine system makes dihedral angles of 45.51 (7) and 44.75 (7)° with the attached 4-fluoro-phenyl ring and the pyridine ring, respectively. The 4-fluoro-phenyl ring makes a dihedral angle of 54.54 (8)° with the pyridine ring. The pyridine ring part of the pyridopyrazine ring and the pyrazine ring of two c-glide-plane-r...
متن کامل3-(4-Methoxyphenyl)pyrido[2,3-b]pyrazine
In the title mol-ecule, C(14)H(11)N(3)O, the benzene ring is twisted by 14.0 (2)° from the plane through the fused ring system. In the crystal, π-π inter-actions [centroid-centroid distances = 3.609 (1), 3.639 (1) and 3.735 (1) Å] form stacks of mol-ecules propagating along the b axis. The crystal packing is further stabilized by weak inter-molecular C-H⋯O and C-H⋯N hydrogen bonds.
متن کامل3-(4-Fluorophenyl)-2-(4-pyridyl)pyrido[2,3-b]pyrazine
In the crystal structure of the title compound, C(18)H(11)FN(4), the pyridopyrazine ring makes dihedral angles of 34.67 (7) and 52.24 (7)° with the 4-fluoro-phenyl and pyridine rings, respectively. The 4-fluoro-phenyl ring makes a dihedral angle of 59.56 (9)° with the pyridine ring.
متن کاملNovel 3-arylethynyl-substituted thieno[3,4-b]pyrazine derivatives as human transglutaminase 2 inhibitors.
In the process of optimization, we developed a novel core skeleton of thieno[3,4-b]pyrazine via GK-13. The derivatives synthesized were shown to inhibit TGase 2 activity in cancer cells. Some of the hit compounds such as the arylethynyl group-coupled thieno[3,4-b]pyrazine derivatives were shown to exhibit promising activity for use as potential therapeutic small-molecules in renal cancer by inh...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1975
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.95.9_1092